Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening

Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions. Dibenzocyclooctyne derivatives (DIBAC and BARAC) were identified to be especially reactive dipolarophiles, which undergo the...

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Detalles Bibliográficos
Autores principales: Narayanam, Maruthi Kumar, Liang, Yong, Houk, K. N., Murphy, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763938/
https://www.ncbi.nlm.nih.gov/pubmed/29910881
http://dx.doi.org/10.1039/c5sc03259h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763938/
https://www.ncbi.nlm.nih.gov/pubmed/29910881
http://dx.doi.org/10.1039/c5sc03259h

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