3’UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells

Most mammalian genes often feature alternative polyadenylation (APA) sites and hence diverse 3’UTR lengths. Proliferating cells were reported to favor APA sites that result in shorter 3’UTRs. One consequence of such shortening is escape of mRNAs from targeting by microRNAs (miRNAs) whose binding sit...

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Detalles Bibliográficos
Autores principales: Hoffman, Yonit, Bublik, Debora Rosa, P. Ugalde, Alejandro, Elkon, Ran, Biniashvili, Tammy, Agami, Reuven, Oren, Moshe, Pilpel, Yitzhak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764332/
https://www.ncbi.nlm.nih.gov/pubmed/26908102
http://dx.doi.org/10.1371/journal.pgen.1005879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764332/
https://www.ncbi.nlm.nih.gov/pubmed/26908102
http://dx.doi.org/10.1371/journal.pgen.1005879

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