An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

Infection by Toxoplasma gondii leads to massive changes to the host cell. Here, we identify a novel host cell effector export pathway that requires the Golgi-resident aspartyl protease 5 (ASP5). We demonstrate that ASP5 cleaves a highly constrained amino acid motif that has similarity to the PEXEL-m...

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Detalles Bibliográficos
Autores principales: Coffey, Michael J, Sleebs, Brad E, Uboldi, Alessandro D, Garnham, Alexandra, Franco, Magdalena, Marino, Nicole D, Panas, Michael W, Ferguson, David JP, Enciso, Marta, O'Neill, Matthew T, Lopaticki, Sash, Stewart, Rebecca J, Dewson, Grant, Smyth, Gordon K, Smith, Brian J, Masters, Seth L, Boothroyd, John C, Boddey, Justin A, Tonkin, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764566/
https://www.ncbi.nlm.nih.gov/pubmed/26576949
http://dx.doi.org/10.7554/eLife.10809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764566/
https://www.ncbi.nlm.nih.gov/pubmed/26576949
http://dx.doi.org/10.7554/eLife.10809

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