More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1

In the early days of HIV treatment, drug resistance occurred rapidly and predictably in all patients, but under modern treatments, resistance arises slowly, if at all. The probability of resistance should be controlled by the rate of generation of resistance mutations. If many adaptive mutations ari...

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Detalles Bibliográficos
Autores principales: Feder, Alison F, Rhee, Soo-Yon, Holmes, Susan P, Shafer, Robert W, Petrov, Dmitri A, Pennings, Pleuni S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764592/
https://www.ncbi.nlm.nih.gov/pubmed/26882502
http://dx.doi.org/10.7554/eLife.10670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764592/
https://www.ncbi.nlm.nih.gov/pubmed/26882502
http://dx.doi.org/10.7554/eLife.10670

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