Cargando…

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis

The activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) are central events in hepatic fibrogenesis. These processes are driven by autocrine- and paracrine-acting soluble factors (i.e., cytokines and chemokines). Proof-of-conce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schon, Hans-Theo, Bartneck, Matthias, Borkham-Kamphorst, Erawan, Nattermann, Jacob, Lammers, Twan, Tacke, Frank, Weiskirchen, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764688/ https://www.ncbi.nlm.nih.gov/pubmed/26941644 http://dx.doi.org/10.3389/fphar.2016.00033

Ejemplares similares

Exercise-Induced Release of Pharmacologically Active Substances and Their Relevance for Therapy of Hepatic Injury
por: Schon, Hans-Theo, et al.
Publicado: (2016)

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
por: Tag, Carmen G., et al.
Publicado: (2015)

Chronic mineral oil administration increases hepatic inflammation in wild type mice compared to lipocalin 2 null mice
por: Borkham-Kamphorst, Erawan, et al.
Publicado: (2021)

N-Glycosylation of Lipocalin 2 Is Not Required for Secretion or Exosome Targeting
por: Borkham-Kamphorst, Erawan, et al.
Publicado: (2018)

Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells
por: Borkham-Kamphorst, Erawan, et al.
Publicado: (2023)

Isolation and Time Lapse Microscopy of Highly Pure Hepatic Stellate Cells
por: Bartneck, Matthias, et al.
Publicado: (2015)

Data on Lipocalin 2 and phosphatidylinositol 3-kinase signaling in a methionine- and choline-deficient model of non-alcoholic steatohepatitis
por: Asimakopoulou, Anastasia, et al.
Publicado: (2017)

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis
por: Krenkel, Oliver, et al.
Publicado: (2019)

Expression analysis of inflammasomes in experimental models of inflammatory and fibrotic liver disease
por: Boaru, Sorina Georgiana, et al.
Publicado: (2012)

Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice through Endoplasmic Reticulum Stress and Unfolded Protein Response
por: Borkham-Kamphorst, Erawan, et al.
Publicado: (2020)

Editorial: Insights in Gastrointestinal and Hepatic Pharmacology: 2021
por: Weiskirchen, Ralf, et al.
Publicado: (2022)

Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice
por: Otto, Julia, et al.
Publicado: (2023)

α2-Adrenergic Receptor in Liver Fibrosis: Implications for the Adrenoblocker Mesedin
por: Schwinghammer, Ute A., et al.
Publicado: (2020)

Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
por: Herrmann, Jens, et al.
Publicado: (2007)

Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis
por: Pu, Shiyun, et al.
Publicado: (2021)

Roles of hepatic stellate cells in NAFLD: From the perspective of inflammation and fibrosis
por: Wang, Man, et al.
Publicado: (2022)

Targeting Activated Hepatic Stellate Cells Using Collagen-Binding Chitosan Nanoparticles for siRNA Delivery to Fibrotic Livers
por: Azzam, Menna, et al.
Publicado: (2020)

Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling
por: Wu, Bingmin, et al.
Publicado: (2022)

Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO Deletion
por: Bartneck, Matthias, et al.
Publicado: (2020)

Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?
por: Chan, Yau-Tuen, et al.
Publicado: (2020)

Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways
por: Li, Zhiyong, et al.
Publicado: (2021)

Functional Contribution of Elevated Circulating and Hepatic Non-Classical CD14(+)CD16(+) Monocytes to Inflammation and Human Liver Fibrosis
por: Zimmermann, Henning W., et al.
Publicado: (2010)

Cellular Mechanisms of Liver Fibrosis
por: Acharya, Pragyan, et al.
Publicado: (2021)

The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels
por: Weiskirchen, Ralf, et al.
Publicado: (2015)

Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling
por: Li, Jingyan, et al.
Publicado: (2023)

Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl(4)-Induced Fibrosis and Human Hepatic Stellate Cells
por: González-Fernández, Bárbara, et al.
Publicado: (2018)

Identification of Pparγ-modulated miRNA hubs that target the fibrotic tumor microenvironment
por: Winkler, Ivana, et al.
Publicado: (2020)

Ferulic Acid Combined With Bone Marrow Mesenchymal Stem Cells Attenuates the Activation of Hepatic Stellate Cells and Alleviates Liver Fibrosis
por: Zhang, Rui, et al.
Publicado: (2022)

SNS-032 attenuates liver fibrosis by anti-active hepatic stellate cells via inhibition of cyclin dependent kinase 9
por: He, Xiao-Li, et al.
Publicado: (2022)

Retraction: Melatonin attenuates dysregulation of the circadian clock pathway in mice with CCl4-induced fibrosis and human hepatic stellate cells
por: Frontiers Editorial Office
Publicado: (2023)

Magnetic-Assisted Treatment of Liver Fibrosis
por: Levada, Kateryna, et al.
Publicado: (2019)

Potential drug mechanism(s) targeting the contractile status of hepatic stellate cells
por: Bucolo, Claudio, et al.
Publicado: (2012)

The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis
por: Hansel, Cordula, et al.
Publicado: (2019)

Recent advances in understanding liver fibrosis: bridging basic science and individualized treatment concepts
por: Weiskirchen, Ralf, et al.
Publicado: (2018)

Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2
por: Tee, Jie Kai, et al.
Publicado: (2018)

Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-κB Signaling Pathway in Hepatic Stellate Cells
por: Wang, Yuan-Hsi, et al.
Publicado: (2020)

The Active Components of Fuzheng Huayu Formula and Their Potential Mechanism of Action in Inhibiting the Hepatic Stellate Cells Viability – A Network Pharmacology and Transcriptomics Approach
por: Xing, Xinrui, et al.
Publicado: (2018)

Exploring the Mechanism of Dangguiliuhuang Decoction Against Hepatic Fibrosis by Network Pharmacology and Experimental Validation
por: Cao, Hui, et al.
Publicado: (2018)

DNA Methylation of PTGIS Enhances Hepatic Stellate Cells Activation and Liver Fibrogenesis
por: Pan, Xue-yin, et al.
Publicado: (2018)

Comparative evaluation of gene delivery devices in primary cultures of rat hepatic stellate cells and rat myofibroblasts
por: Weiskirchen, Ralf, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_m8407ea9us5jlvm67umo7llk59