Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

Marburg virus (MARV) is an Ebola-like virus in the family Filovirdae that causes sporadic outbreaks of severe hemorrhagic fever with a case fatality rate as high as 90%. AVI-7288, a positively charged antisense phosphorodiamidate morpholino oligomer (PMOplus) targeting the viral nucleoprotein gene,...

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Detalles Bibliográficos
Autores principales: Warren, Travis K., Whitehouse, Chris A., Wells, Jay, Welch, Lisa, Charleston, Jay S., Heald, Alison, Nichols, Donald K., Mattix, Marc E., Palacios, Gustavo, Kugleman, Jeffrey R., Iversen, Patrick L., Bavari, Sina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764691/
https://www.ncbi.nlm.nih.gov/pubmed/26901785
http://dx.doi.org/10.1371/journal.pntd.0004456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764691/
https://www.ncbi.nlm.nih.gov/pubmed/26901785
http://dx.doi.org/10.1371/journal.pntd.0004456

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