Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain

In animal models, neonatal exposure to general anesthetics significantly increased neuronal apoptosis with subsequent behavioral deficits in adulthood. Although the underlying mechanism is largely unknown, involvement of extracellular signal-regulated kinases (ERKs) is speculated since ERK phosphory...

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Detalles Bibliográficos
Autores principales: Yufune, Shinya, Satoh, Yasushi, Akai, Ryosuke, Yoshinaga, Yosuke, Kobayashi, Yasushi, Endo, Shogo, Kazama, Tomiei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764822/
https://www.ncbi.nlm.nih.gov/pubmed/26905012
http://dx.doi.org/10.1038/srep21859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764822/
https://www.ncbi.nlm.nih.gov/pubmed/26905012
http://dx.doi.org/10.1038/srep21859

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