Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that serves as a pleotropic regulator of whole body energy homoeostasis. AMPK exists as a heterotrimeric complex, composed of a catalytic subunit (α) and two regulatory subunits (β and γ), each present as multiple isoforms. In...

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Detalles Bibliográficos
Autores principales: Rajamohan, Francis, Reyes, Allan R., Frisbie, Richard K., Hoth, Lise R., Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A., Withka, Jane M., Caspers, Nicole L., Calabrese, Matthew F., Ward, Jessica, Kurumbail, Ravi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764975/
https://www.ncbi.nlm.nih.gov/pubmed/26635351
http://dx.doi.org/10.1042/BJ20151051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764975/
https://www.ncbi.nlm.nih.gov/pubmed/26635351
http://dx.doi.org/10.1042/BJ20151051

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