Cargando…

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that serves as a pleotropic regulator of whole body energy homoeostasis. AMPK exists as a heterotrimeric complex, composed of a catalytic subunit (α) and two regulatory subunits (β and γ), each present as multiple isoforms. In...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajamohan, Francis, Reyes, Allan R., Frisbie, Richard K., Hoth, Lise R., Sahasrabudhe, Parag, Magyar, Rachelle, Landro, James A., Withka, Jane M., Caspers, Nicole L., Calabrese, Matthew F., Ward, Jessica, Kurumbail, Ravi G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764975/ https://www.ncbi.nlm.nih.gov/pubmed/26635351 http://dx.doi.org/10.1042/BJ20151051

Ejemplares similares

Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq
por: van Unen, Jakobus, et al.
Publicado: (2016)

Exploring allosteric coupling in the α-subunit of Heterotrimeric G proteins using evolutionary and ensemble-based approaches
por: Sayar, Kemal, et al.
Publicado: (2008)

Activation of Nrf2 by Lithospermic Acid Ameliorates Myocardial Ischemia and Reperfusion Injury by Promoting Phosphorylation of AMP-Activated Protein Kinase α (AMPKα)
por: Zhang, Min, et al.
Publicado: (2021)

Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
por: Yamada, Eijiro, et al.
Publicado: (2016)

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
por: Wang, Songbo, et al.
Publicado: (2015)

Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease
por: Rajamohan, Francis, et al.
Publicado: (2020)

Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa
por: Lokits, A. D., et al.
Publicado: (2018)

The heterotrimeric G protein subunits Gα(q) and Gβ(1) have lysophospholipase D activity
por: Aoyama, Chieko, et al.
Publicado: (2011)

Interplay between the heterotrimeric G-protein subunits G(αq )and G(αi2 )sets the threshold for chemotaxis and TCR activation
por: Ngai, Jacob, et al.
Publicado: (2009)

Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1
por: Zhao, Liang, et al.
Publicado: (2018)

Allosteric activation of PI3Kα by oncogenic mutations
por: Burke, John E., et al.
Publicado: (2013)

Allosteric regulation of C. elegans AMP-activated protein kinase
por: Scanlon, Daniel M, et al.
Publicado: (2022)

AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications
por: Kumagai, Asako, et al.
Publicado: (2018)

AMP-independent activator of AMPK for treatment of mitochondrial disorders
por: Moore, Tereza, et al.
Publicado: (2020)

Cordycepin Inhibits Lipopolysaccharide (LPS)-Induced Tumor Necrosis Factor (TNF)-α Production via Activating AMP-Activated Protein Kinase (AMPK) Signaling
por: Zhang, Jian-Li, et al.
Publicado: (2014)

Heterotrimeric G Proteins in Plants: Canonical and Atypical Gα Subunits
por: Maruta, Natsumi, et al.
Publicado: (2021)

State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides
por: Dai, Shizhong A., et al.
Publicado: (2022)

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation
por: Gowans, Graeme J., et al.
Publicado: (2013)

Allosteric inhibition of α-thrombin enzymatic activity with ultrasmall gold nanoparticles
por: Lira, André L., et al.
Publicado: (2018)

Activation of the AMP-Activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells
por: Wu, Yong, et al.
Publicado: (2012)

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly
por: Hinchy, Elizabeth C., et al.
Publicado: (2018)

Activation of AMP-activated protein kinase (AMPK) through inhibiting interaction with prohibitins
por: Kanagaki, Shuhei, et al.
Publicado: (2023)

Nitric oxide increases cyclic GMP levels, AMP-activated protein kinase (AMPK)α1-specific activity and glucose transport in human skeletal muscle
por: Deshmukh, A. S., et al.
Publicado: (2010)

Specific Deletion of AMP-Activated Protein Kinase (α1AMPK) in Murine Oocytes Alters Junctional Protein Expression and Mitochondrial Physiology
por: Bertoldo, Michael J., et al.
Publicado: (2015)

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain
por: Ramamurthy, Santosh, et al.
Publicado: (2012)

Roles of AMP-Activated Protein Kinase (AMPK) in Mammalian Reproduction
por: Yang, Weina, et al.
Publicado: (2020)

The α-subunit of the heterotrimeric G-protein affects jasmonate responses in Arabidopsis thaliana
por: Okamoto, Haruko, et al.
Publicado: (2009)

Role of heterotrimeric Gα proteins in maize development and enhancement of agronomic traits
por: Wu, Qingyu, et al.
Publicado: (2018)

Saxagliptin enhances osteogenic differentiation in MC3T3-E1 cells, dependent on the activation of AMP-activated protein kinase α (AMPKα)/runt-related transcription factor-2 (Runx-2)
por: Wang, Qiang, et al.
Publicado: (2022)

Optogenetic activation of heterotrimeric G-proteins by LOV2GIVe, a rationally engineered modular protein
por: Garcia-Marcos, Mikel, et al.
Publicado: (2020)

Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity
por: Rubio, Teresa, et al.
Publicado: (2013)

AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer
por: Jhaveri, Teraneh Z., et al.
Publicado: (2015)

Retraction: Activation of the AMP-Activated Protein Kinase (AMPK) by Nitrated Lipids in Endothelial Cells
Publicado: (2020)

Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway
por: Wang, Hui‐Bo, et al.
Publicado: (2019)

AMP-Activated Kinase AMPK Is Expressed in Boar Spermatozoa and Regulates Motility
por: Hurtado de Llera, Ana, et al.
Publicado: (2012)

Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer
por: Andrade, Bruno Moulin, et al.
Publicado: (2014)

AMP-Activated Protein Kinase (AMPK)-Dependent Regulation of Renal Transport
por: Glosse, Philipp, et al.
Publicado: (2018)

AMPKα2 knockout enhances tumour inflammation through exacerbated liver injury and energy deprivation‐associated AMPKα1 activation
por: Qiu, Shulan, et al.
Publicado: (2019)

Competing Activities of Heterotrimeric G Proteins in Drosophila Wing Maturation
por: Katanayeva, Natalya, et al.
Publicado: (2010)

Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G(13)
por: Guo, Xueshui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_blf4geisb09qccg34k7c216aiu