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Structure-based Markov random field model for representing evolutionary constraints on functional sites

BACKGROUND: Elucidating the cooperative mechanism of interconnected residues is an important component toward understanding the biological function of a protein. Coevolution analysis has been developed to model the coevolutionary information reflecting structural and functional constraints. Recently...

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Detalles Bibliográficos
Autores principales: Jeong, Chan-Seok, Kim, Dongsup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765150/
https://www.ncbi.nlm.nih.gov/pubmed/26911566
http://dx.doi.org/10.1186/s12859-016-0948-2