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Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4

Cytotoxic effects of cisplatin occur primarily through apoptosis. Though several pro- and anti-apoptotic signaling molecules have been identified to play an important role in mediating the ototoxic, nephrotoxic, and neurotoxic side effects of cisplatin, the underlying mechanism is yet to be fully ch...

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Detalles Bibliográficos
Autores principales: Rathinam, R, Ghosh, S, Neumann, WL, Jamesdaniel, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765951/
https://www.ncbi.nlm.nih.gov/pubmed/26925255
http://dx.doi.org/10.1038/cddiscovery.2015.52