Phase 1 Safety and Immunogenicity Study of a Quadrivalent Seasonal Flu Vaccine Comprising Recombinant Hemagglutinin-Flagellin Fusion Proteins

Background. We evaluated the safety and immunogenicity of VAX2012Q, a quadrivalent influenza vaccine comprising 4 hemagglutinin subunits fused to flagellin. Methods. In this dose-ranging, open-label study, healthy adults (18–40 years) were divided into 7 cohorts for evaluation of 5 dose levels and 3...

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Detalles Bibliográficos
Autores principales: Tussey, Lynda, Strout, Cynthia, Davis, Matthew, Johnson, Casey, Lucksinger, Gregg, Umlauf, Scott, Song, Langzhou, Liu, Ge, Abraham, Katalin, White, C. Jo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Major Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766387/
https://www.ncbi.nlm.nih.gov/pubmed/26925433
http://dx.doi.org/10.1093/ofid/ofw015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766387/
https://www.ncbi.nlm.nih.gov/pubmed/26925433
http://dx.doi.org/10.1093/ofid/ofw015

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