Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity

Chronic cadmium (Cd) exposure can induce renal toxicity. In Cd renal toxicity, p53 is thought to be involved. Our previous studies showed that Cd down-regulated gene expression of the UBE2D (ubiquitin-conjugating enzyme E2D) family members. Here, we aimed to define the association between UBE2D fami...

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Detalles Bibliográficos
Autores principales: Lee, Jin-Yong, Tokumoto, Maki, Fujiwara, Yasuyuki, Hasegawa, Tatsuya, Seko, Yoshiyuki, Shimada, Akinori, Satoh, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766413/
https://www.ncbi.nlm.nih.gov/pubmed/26912277
http://dx.doi.org/10.1038/srep21968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766413/
https://www.ncbi.nlm.nih.gov/pubmed/26912277
http://dx.doi.org/10.1038/srep21968

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