Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson...

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Detalles Bibliográficos
Autores principales: Sant'Anna, Ricardo, Gallego, Pablo, Robinson, Lei Z., Pereira-Henriques, Alda, Ferreira, Nelson, Pinheiro, Francisca, Esperante, Sebastian, Pallares, Irantzu, Huertas, Oscar, Rosário Almeida, Maria, Reixach, Natàlia, Insa, Raul, Velazquez-Campoy, Adrian, Reverter, David, Reig, Núria, Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766415/
https://www.ncbi.nlm.nih.gov/pubmed/26902880
http://dx.doi.org/10.1038/ncomms10787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766415/
https://www.ncbi.nlm.nih.gov/pubmed/26902880
http://dx.doi.org/10.1038/ncomms10787

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