Cargando…

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sant'Anna, Ricardo, Gallego, Pablo, Robinson, Lei Z., Pereira-Henriques, Alda, Ferreira, Nelson, Pinheiro, Francisca, Esperante, Sebastian, Pallares, Irantzu, Huertas, Oscar, Rosário Almeida, Maria, Reixach, Natàlia, Insa, Raul, Velazquez-Campoy, Adrian, Reverter, David, Reig, Núria, Ventura, Salvador
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766415/ https://www.ncbi.nlm.nih.gov/pubmed/26902880 http://dx.doi.org/10.1038/ncomms10787

Ejemplares similares

Author Correction: Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity
por: Sant’Anna, Ricardo, et al.
Publicado: (2023)

Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation
por: Pinheiro, Francisca, et al.
Publicado: (2022)

A molecular mechanism for transthyretin amyloidogenesis
por: Yee, Ai Woon, et al.
Publicado: (2019)

Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation
por: Sant’Anna, Ricardo, et al.
Publicado: (2017)

Plasminogen activation triggers transthyretin amyloidogenesis in vitro
por: Mangione, P. Patrizia, et al.
Publicado: (2018)

Review on the Structures and Activities of Transthyretin Amyloidogenesis Inhibitors
por: Guo, Xiaohua, et al.
Publicado: (2020)

Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation
por: Esperante, Sebastián A., et al.
Publicado: (2021)

Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone’s Particle Size on Sustained Release
por: Nardi-Ricart, Anna, et al.
Publicado: (2020)

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
por: Marcoux, Julien, et al.
Publicado: (2015)

Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans
por: Mohankumar, Amirthalingam, et al.
Publicado: (2022)

Differential Interactome Based Drug Repositioning Unraveled Abacavir, Exemestane, Nortriptyline Hydrochloride, and Tolcapone as Potential Therapeutics for Colorectal Cancers
por: Beklen, Hande, et al.
Publicado: (2021)

Utility of tolcapone in fluctuating Parkinson’s disease
por: Stocchi, Fabrizio, et al.
Publicado: (2006)

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel
por: Verona, Guglielmo, et al.
Publicado: (2017)

Effects of tolcapone and bromocriptine on cognitive stability and flexibility
por: Cameron, Ian G. M., et al.
Publicado: (2018)

SOM0226, a repositioned compound for the treatment of TTR amyloidosis
por: Reig, Núria, et al.
Publicado: (2015)

The efficacy of homemade tolcapone in the treatment of patients with Parkinsons disease
por: Zhang, Pei-Lan, et al.
Publicado: (2018)

Safety and efficacy of tolcapone in Parkinson’s disease: systematic review
por: Artusi, Carlo Alberto, et al.
Publicado: (2021)

Micro- and Nano-Systems Developed for Tolcapone in Parkinson’s Disease
por: Casanova, Yaquelyn, et al.
Publicado: (2022)

Cofactor-mediated amyloidogenesis
por: Madine, Jillian
Publicado: (2019)

Microbiome Impact on Amyloidogenesis
por: Seira Curto, Jofre, et al.
Publicado: (2022)

The Importance of a Gatekeeper Residue on the Aggregation of Transthyretin: IMPLICATIONS FOR TRANSTHYRETIN-RELATED AMYLOIDOSES
por: Sant'Anna, Ricardo, et al.
Publicado: (2014)

Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors
por: Bhakta, Savita G, et al.
Publicado: (2017)

Modulating the Amyloidogenesis of α-Synuclein
por: Sivanesam, Kalkena, et al.
Publicado: (2016)

Transthyretin deposition promotes progression of osteoarthritis
por: Matsuzaki, Tokio, et al.
Publicado: (2017)

Quantification of Quaternary Structure Stability in Aggregation-Prone Proteins under Physiological Conditions: The Transthyretin Case
por: Robinson, Lei Z., et al.
Publicado: (2014)

Tolcapone: review of its pharmacology and use as adjunctive therapy in patients with Parkinson’s disease
por: Truong, Daniel D
Publicado: (2009)

Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma
por: Maser, Tyler, et al.
Publicado: (2017)

Discovering Putative Prion-Like Proteins in Plasmodium falciparum: A Computational and Experimental Analysis
por: Pallarès, Irantzu, et al.
Publicado: (2018)

Discovery of γ-Mangostin as an Amyloidogenesis Inhibitor
por: Yokoyama, Takeshi, et al.
Publicado: (2015)

Amyloidogenic and non-amyloidogenic transthyretin variants interact differently with human cardiomyocytes: insights into early events of non-fibrillar tissue damage
por: Manral, Pallavi, et al.
Publicado: (2015)

Right inferior frontal cortex activity correlates with tolcapone responsivity in problem and pathological gamblers
por: Kayser, Andrew S., et al.
Publicado: (2016)

Addition of Tolcapone in Intrajejunal Levodopa Infusion Therapy Requires a Pronounced Dose Reduction
por: Schröter, Nils, et al.
Publicado: (2020)

Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses
por: Qiu, Mengjie, et al.
Publicado: (2020)

Molecular Tweezers Targeting Transthyretin Amyloidosis
por: Ferreira, Nelson, et al.
Publicado: (2014)

Functional Amyloidogenesis and Cytotoxicity—Insights into Biology and Pathology
por: Fowler, Douglas M., et al.
Publicado: (2012)

Prediction and Analysis of Antibody Amyloidogenesis from Sequences
por: Liaw, Chyn, et al.
Publicado: (2013)

Clusterin transduces Alzheimer-risk signals to amyloidogenesis
por: Liu, Xi, et al.
Publicado: (2022)

Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats
por: Mihaylova, Anita, et al.
Publicado: (2019)

Tolcapone in Obsessive Compulsive disorder: A Randomized Double-Blind Placebo-Controlled Crossover Trial
por: Grant, Jon E., et al.
Publicado: (2021)

Transthyretin chemical chaperoning by flavonoids: Structure–activity insights towards the design of potent amyloidosis inhibitors
por: Ferreira, Nelson, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hgkonhfle09rnn88hjk158c46r