Cargando…

Detection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance

Cytochrome P450 monooxygenases typically catalyze the insertion of one atom of oxygen from O(2) into unactivated carbon-hydrogen and carbon-carbon bonds, with concomitant reduction of the other oxygen atom to H(2)O by NAD(P)H. Comparison of the average structures of the camphor hydroxylase cytochrom...

Descripción completa

Detalles Bibliográficos
Autores principales: Colthart, Allison M., Tietz, Drew R., Ni, Yuhua, Friedman, Jessica L., Dang, Marina, Pochapsky, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766564/
https://www.ncbi.nlm.nih.gov/pubmed/26911901
http://dx.doi.org/10.1038/srep22035