CRISPR/Cas9-mediated GJA8 knockout in rabbits recapitulates human congenital cataracts

Cataracts are the leading cause of vision loss in the world, although surgical treatment can restore vision in cataract patients. Until now, there have been no adequate animal models for in vivo studies of artificial lens safety and drug interactions. Genetic studies have demonstrated that GJA8 is i...

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Detalles Bibliográficos
Autores principales: Yuan, Lin, Sui, Tingting, Chen, Mao, Deng, Jichao, Huang, Yongye, Zeng, Jian, Lv, Qingyan, Song, Yuning, Li, Zhanjun, Lai, Liangxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766569/
https://www.ncbi.nlm.nih.gov/pubmed/26912477
http://dx.doi.org/10.1038/srep22024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766569/
https://www.ncbi.nlm.nih.gov/pubmed/26912477
http://dx.doi.org/10.1038/srep22024

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