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Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II)
BACKGROUND: The ability to site-specifically conjugate a protein to a payload of interest (e.g., a fluorophore, small molecule pharmacophore, oligonucleotide, or other protein) has found widespread application in basic research and drug development. For example, antibody-drug conjugates represent a...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766608/ https://www.ncbi.nlm.nih.gov/pubmed/26911368 http://dx.doi.org/10.1186/s12896-016-0254-0 |