Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma

BACKGROUND: Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC). METHODS: We investigated the effect of resveratrol (RES), an edible polyphenol phytoa...

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Detalles Bibliográficos
Autores principales: Kim, Chulwon, Baek, Sang Hyun, Um, Jae-Young, Shim, Bum Sang, Ahn, Kwang Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766620/
https://www.ncbi.nlm.nih.gov/pubmed/26911335
http://dx.doi.org/10.1186/s12882-016-0233-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766620/
https://www.ncbi.nlm.nih.gov/pubmed/26911335
http://dx.doi.org/10.1186/s12882-016-0233-7

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