Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

INTRODUCTION: Mutations of Tau are associated with several neurodegenerative disorders. Recently, the Tau mutation A152T was described as a novel risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. In vitro Tau-A152T shows a decreased binding to microtubules and a reduc...

Descripción completa

Detalles Bibliográficos
Autores principales: Sydow, Astrid, Hochgräfe, Katja, Könen, Stefanie, Cadinu, Daniela, Matenia, Dorthe, Petrova, Olga, Joseph, Maria, Dennissen, Frank Johannes, Mandelkow, Eva-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766625/
https://www.ncbi.nlm.nih.gov/pubmed/26916334
http://dx.doi.org/10.1186/s40478-016-0281-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766625/
https://www.ncbi.nlm.nih.gov/pubmed/26916334
http://dx.doi.org/10.1186/s40478-016-0281-z

Ejemplares similares