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Age-dependent neuroinflammation and cognitive decline in a novel Ala152Thr-Tau transgenic mouse model of PSP and AD

INTRODUCTION: Mutations of Tau are associated with several neurodegenerative disorders. Recently, the Tau mutation A152T was described as a novel risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. In vitro Tau-A152T shows a decreased binding to microtubules and a reduc...

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Detalles Bibliográficos
Autores principales:	Sydow, Astrid, Hochgräfe, Katja, Könen, Stefanie, Cadinu, Daniela, Matenia, Dorthe, Petrova, Olga, Joseph, Maria, Dennissen, Frank Johannes, Mandelkow, Eva-Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766625/ https://www.ncbi.nlm.nih.gov/pubmed/26916334 http://dx.doi.org/10.1186/s40478-016-0281-z

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