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ERK2 and Akt are negative regulators of insulin and Tumor Necrosis Factor-α stimulated VCAM-1 expression in rat aorta endothelial cells

BACKGROUND: Diabetes is quickly becoming the most widespread disorder in the Western world. Among the most prevalent effects of diabetes is atherosclerosis, which in turn is driven in part by inflammation. Both insulin and Tumor Necrosis Factor-alpha (TNFα) increase the presence of Vascular Cellular...

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Detalles Bibliográficos
Autores principales: Pott, Gregory B., Tsurudome, Mark, Bamfo, Nadia, Goalstone, Marc L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766666/
https://www.ncbi.nlm.nih.gov/pubmed/26917991
http://dx.doi.org/10.1186/s12950-016-0115-6