Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

BACKGROUND: Aberrant Hedgehog (Hh) signaling is associated with the development of many cancers including prostate cancer, gastrointestinal cancer, lung cancer, pancreatic cancer, ovarian cancer, and basal cell carcinoma. The Hh signaling pathway has been one of the most intensely investigated targe...

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Detalles Bibliográficos
Autores principales: Alam, Md Maksudul, Sohoni, Sagar, Kalainayakan, Sarada Preeta, Garrossian, Massoud, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766751/
https://www.ncbi.nlm.nih.gov/pubmed/26911235
http://dx.doi.org/10.1186/s12885-016-2200-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766751/
https://www.ncbi.nlm.nih.gov/pubmed/26911235
http://dx.doi.org/10.1186/s12885-016-2200-x

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