Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells

Tissue inhibitors of metalloproteinases (TIMPs) control extracellular matrix (ECM) homeostasis by inhibiting the activity of matrix metalloproteinases (MMPs), which are associated with ECM turnover. Recent studies have revealed that TIMPs are implicated in tumorigenesis in both MMP-dependent and MMP...

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Detalles Bibliográficos
Autores principales: Kim, Han Ie, Lee, Hyun-Sung, Kim, Tae Hyun, Lee, Ju-Seog, Lee, Seung-Taek, Lee, Seo-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767480/
https://www.ncbi.nlm.nih.gov/pubmed/26556867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767480/
https://www.ncbi.nlm.nih.gov/pubmed/26556867

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