Molecular Probing of the HPV-16 E6 Protein Alpha Helix Binding Groove with Small Molecule Inhibitors

The human papillomavirus (HPV) HPV E6 protein has emerged as a central oncoprotein in HPV-associated cancers in which sustained expression is required for tumor progression. A majority of the E6 protein interactions within the human proteome use an alpha-helix groove interface for binding. The UBE3A...

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Detalles Bibliográficos
Autores principales: Rietz, Anne, Petrov, Dino P., Bartolowits, Matthew, DeSmet, Marsha, Davisson, V. Jo, Androphy, Elliot J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767726/
https://www.ncbi.nlm.nih.gov/pubmed/26915086
http://dx.doi.org/10.1371/journal.pone.0149845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767726/
https://www.ncbi.nlm.nih.gov/pubmed/26915086
http://dx.doi.org/10.1371/journal.pone.0149845

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