A survey of new oncology drug approvals in the USA from 2010 to 2015: a focus on optimal dose and related postmarketing activities

The maximally tolerated dose (MTD) of cytotoxic agents has historical precedence in treating cancer, as it was believed that dose and therapeutic effect are intrinsically linked and that the MTD would provide greatest therapeutic value. With molecularly targeted agents, the premise of preventing tox...

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Detalles Bibliográficos
Autores principales: Lu, Dan, Lu, Tong, Stroh, Mark, Graham, Richard A., Agarwal, Priya, Musib, Luna, Li, Chi-Chung, Lum, Bert L., Joshi, Amita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767861/
https://www.ncbi.nlm.nih.gov/pubmed/26811176
http://dx.doi.org/10.1007/s00280-015-2931-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767861/
https://www.ncbi.nlm.nih.gov/pubmed/26811176
http://dx.doi.org/10.1007/s00280-015-2931-4

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