High Sulfation and a High Molecular Weight Are Important for Anti-hepcidin Activity of Heparin

Heparins are efficient inhibitors of hepcidin expression even in vivo, where they induce an increase of systemic iron availability. Heparins seem to act by interfering with BMP6 signaling pathways that control the expression of liver hepcidin, causing the suppression of SMAD1/5/8 phosphorylation. Th...

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Detalles Bibliográficos
Autores principales: Asperti, Michela, Naggi, Annamaria, Esposito, Emiliano, Ruzzenenti, Paola, Di Somma, Margherita, Gryzik, Magdalena, Arosio, Paolo, Poli, Maura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768129/
https://www.ncbi.nlm.nih.gov/pubmed/26955355
http://dx.doi.org/10.3389/fphar.2015.00316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768129/
https://www.ncbi.nlm.nih.gov/pubmed/26955355
http://dx.doi.org/10.3389/fphar.2015.00316

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