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High Sulfation and a High Molecular Weight Are Important for Anti-hepcidin Activity of Heparin
Heparins are efficient inhibitors of hepcidin expression even in vivo, where they induce an increase of systemic iron availability. Heparins seem to act by interfering with BMP6 signaling pathways that control the expression of liver hepcidin, causing the suppression of SMAD1/5/8 phosphorylation. Th...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768129/ https://www.ncbi.nlm.nih.gov/pubmed/26955355 http://dx.doi.org/10.3389/fphar.2015.00316 |