Biliverdin targets enolase and eukaryotic initiation factor 2 (eIF2α) to reduce the growth of intraerythrocytic development of the malaria parasite Plasmodium falciparum

In mammals, haem degradation to biliverdin (BV) through the action of haem oxygenase (HO) is a critical step in haem metabolism. The malaria parasite converts haem into the chemically inert haemozoin to avoid toxicity. We discovered that the knock-out of HO in P. berghei is lethal; therefore, we inv...

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Detalles Bibliográficos
Autores principales: Alves, Eduardo, Maluf, Fernando V., Bueno, Vânia B., Guido, Rafael V. C., Oliva, Glaucius, Singh, Maneesh, Scarpelli, Pedro, Costa, Fahyme, Sartorello, Robson, Catalani, Luiz H., Brady, Declan, Tewari, Rita, Garcia, Celia R. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768138/
https://www.ncbi.nlm.nih.gov/pubmed/26915471
http://dx.doi.org/10.1038/srep22093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768138/
https://www.ncbi.nlm.nih.gov/pubmed/26915471
http://dx.doi.org/10.1038/srep22093

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