Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells

The prominent role of Fanconi anemia (FA) proteins involves homologous recombination (HR) repair. Poly[ADP-ribose] polymerase1 (PARP1) functions in multiple cellular processes including DNA repair and PARP inhibition is an emerging targeted therapy for cancer patients deficient in HR. Here we show t...

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Detalles Bibliográficos
Autores principales: Du, Wei, Amarachintha, Surya, Wilson, Andrew F., Pang, Qishen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768158/
https://www.ncbi.nlm.nih.gov/pubmed/26916217
http://dx.doi.org/10.1038/srep22167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768158/
https://www.ncbi.nlm.nih.gov/pubmed/26916217
http://dx.doi.org/10.1038/srep22167

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