The Macrophage-depleting Agent Clodronate Promotes Durable Hematopoietic Chimerism and Donor-specific Skin Allograft Tolerance in Mice

Hematopoietic chimerism is known to promote donor-specific organ allograft tolerance; however, clinical translation has been impeded by the requirement for toxic immunosuppression and large doses of donor bone marrow (BM) cells. Here, we investigated in mice whether durable chimerism might be enhanc...

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Detalles Bibliográficos
Autores principales: Li, Zhanzhuo, Xu, Xin, Feng, Xingmin, Murphy, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768260/
https://www.ncbi.nlm.nih.gov/pubmed/26917238
http://dx.doi.org/10.1038/srep22143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768260/
https://www.ncbi.nlm.nih.gov/pubmed/26917238
http://dx.doi.org/10.1038/srep22143

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