Challenges to increasing targeting efficiency in genome engineering

Gene targeting technologies are essential for the analysis of gene functions. Knockout mouse generation via genetic modification of embryonic stem cells (ESCs) is the commonest example, but it is a time-consuming and labor-intensive procedure. Recently, a novel genome editing technology called CRISP...

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Detalles Bibliográficos
Autores principales: HORII, Takuro, HATADA, Izuho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Society for Reproduction and Development 2015
Materias:
Opinions and Hypotheses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768773/
https://www.ncbi.nlm.nih.gov/pubmed/26688299
http://dx.doi.org/10.1262/jrd.2015-151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768773/
https://www.ncbi.nlm.nih.gov/pubmed/26688299
http://dx.doi.org/10.1262/jrd.2015-151

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