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Challenges to increasing targeting efficiency in genome engineering
Gene targeting technologies are essential for the analysis of gene functions. Knockout mouse generation via genetic modification of embryonic stem cells (ESCs) is the commonest example, but it is a time-consuming and labor-intensive procedure. Recently, a novel genome editing technology called CRISP...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Society for Reproduction and Development
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768773/ https://www.ncbi.nlm.nih.gov/pubmed/26688299 http://dx.doi.org/10.1262/jrd.2015-151 |