Cargando…

Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase

Metformin, the most widely administered oral anti-diabetic therapeutic agent, exerts its glucose-lowering effect predominantly via liver kinase B1 (LKB1)-dependent activation of adenosine monophosphate-activated protein kinase (AMPK). Accumulating evidence has demonstrated that metformin possesses p...

Descripción completa

Detalles Bibliográficos
Autores principales:	GUO, QIANQIAN, LIU, ZHIYAN, JIANG, LILI, LIU, MENGJIE, MA, JIEQUN, YANG, CHENGCHENG, HAN, LILI, NAN, KEJUN, LIANG, XUAN
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768996/ https://www.ncbi.nlm.nih.gov/pubmed/26847819 http://dx.doi.org/10.3892/mmr.2016.4830

Ejemplares similares

Adenosine monophosphate–activated protein kinase in diabetic nephropathy
por: Kim, Yaeni, et al.
Publicado: (2016)

Metformin directly suppresses atherosclerosis in normoglycaemic mice via haematopoietic adenosine monophosphate-activated protein kinase
por: Seneviratne, Anusha, et al.
Publicado: (2020)

Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase
por: Tsai, Wei-Lun, et al.
Publicado: (2017)

Cytoplasmic liver kinase B1 promotes the growth of human lung adenocarcinoma by enhancing autophagy
por: Liu, Mengjie, et al.
Publicado: (2018)

Roles of adenosine monophosphate-activated protein kinase (AMPK) in the kidney
por: Zhu, Na, et al.
Publicado: (2022)

Adenosine-Mono-Phosphate-Activated Protein Kinase-Independent Effects of Metformin in T Cells
por: Zarrouk, Marouan, et al.
Publicado: (2014)

Diabetic conditions modulate the adenosine monophosphate-activated protein kinase of podocytes
por: Ha, Tae-Sun, et al.
Publicado: (2014)

Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
por: Hajra, A, et al.
Publicado: (2017)

Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy
por: Dutta, D, et al.
Publicado: (2017)

Bidirectional regulation of adenosine 5′‐monophosphate–activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration
por: Xiao, Yuanyuan, et al.
Publicado: (2018)

Role of the Peroxisome Proliferator-Activated Receptors, Adenosine Monophosphate-Activated Kinase, and Adiponectin in the Ovary
por: Dupont, Joëlle, et al.
Publicado: (2008)

Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the Central Nervous System of Rats
por: Shi, Xing-Xing, et al.
Publicado: (2016)

Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds
por: Marín-Aguilar, Fabiola, et al.
Publicado: (2017)

Electroacupuncture preconditioning attenuates ischemic brain injury by activation of the adenosine monophosphate-activated protein kinase signaling pathway
por: Ran, Qiang-qiang, et al.
Publicado: (2015)

Enhanced Production of Adenosine Triphosphate by Pharmacological Activation of Adenosine Monophosphate-Activated Protein Kinase Ameliorates Acetaminophen-Induced Liver Injury
por: Hwang, Jung Hwan, et al.
Publicado: (2015)

Metformin Enhanced in Vitro Radiosensitivity Associates with G2/M Cell Cycle Arrest and Elevated Adenosine-5’-monophosphate-activated Protein Kinase Levels in Glioblastoma
por: Adeberg, Sebastian, et al.
Publicado: (2017)

Activation of Adenosine Monophosphate—Activated Protein Kinase Reduces the Onset of Diet‐Induced Hepatocellular Carcinoma in Mice
por: Schmoll, Dieter, et al.
Publicado: (2020)

LDL-cholesterol reduction in patients with hypercholesterolemia by modulation of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase
por: Filippov, Sergey, et al.
Publicado: (2014)

Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate‐activated protein kinase‐related kinases and retinoid X receptor α
por: Satoh, Shinya, et al.
Publicado: (2017)

Liraglutide suppresses the proliferation of endometrial cancer cells through the adenosine 5′-monophosphate (AMP)-activated protein kinase signaling pathway
por: Zhu, Xin-Xin, et al.
Publicado: (2021)

Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apoptosis in a mouse model of amyotrophic lateral sclerosis
por: Sui, Yanling, et al.
Publicado: (2014)

Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase
por: Ali, Akhtar, et al.
Publicado: (2018)

Adenosine monophosphate kinase activator α‐lipoic acid: A promising therapeutic agent for metabolic syndrome?
por: Lee, In‐Kyu
Publicado: (2011)

Effects of ischemic preconditioning on mitochondrial and metabolic neruoprotection: 5’ adenosine monophosphate-activated protein kinase and sirtuins
por: Jackson, Charles W, et al.
Publicado: (2018)

Effects of dietary energy level on appetite and central adenosine monophosphate-activated protein kinase (AMPK) in broilers
por: Hu, Xiyi, et al.
Publicado: (2019)

Adenosine monophosphate activated protein kinase contributes to skeletal muscle health through the control of mitochondrial function
por: Yan, Yan, et al.
Publicado: (2022)

Identification of Direct Activator of Adenosine Monophosphate-Activated Protein Kinase (AMPK) by Structure-Based Virtual Screening and Molecular Docking Approach
por: Huang, Tonghui, et al.
Publicado: (2017)

Neuroprotective effect of activated 5′-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation
por: Kamoshita, Mamoru, et al.
Publicado: (2016)

Reply to letter to editor regarding the article, “Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapy”
por: Dutta, D, et al.
Publicado: (2017)

Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase α1
por: Kang, Hyo Jae, et al.
Publicado: (2021)

Adenosine Monophosphate-Activated Protein Kinase (AMPK) Phosphorylation Is Required for 20-Hydroxyecdysone Regulates Ecdysis in Apolygus lucorum
por: Tan, Yongan, et al.
Publicado: (2023)

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells
por: Yamaguchi, Hiroshi, et al.
Publicado: (2014)

Alpha-Mangostin Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice Partly Through Activating Adenosine 5′-Monophosphate-Activated Protein Kinase
por: Li, Ren-shi, et al.
Publicado: (2019)

Adenosine 5'‐monophosphate‐activated protein kinase‐dependent mTOR pathway is involved in flavokawain B‐induced autophagy in thyroid cancer cells
por: He, Qin, et al.
Publicado: (2018)

Metformin promotes angiogenesis and functional recovery in aged mice after spinal cord injury by adenosine monophosphate-activated protein kinase/endothelial nitric oxide synthase pathway
por: Zhao, Jin-Yun, et al.
Publicado: (2022)

High Skp2/Low p57(Kip2) Expression is Associated with Poor Prognosis in Human Breast Carcinoma
por: Yang, Chengcheng, et al.
Publicado: (2015)

MicroRNA-7450 regulates non-thermal plasma-induced chicken Sertoli cell apoptosis via adenosine monophosphate-activated protein kinase activation
por: Zhang, Jiao Jiao, et al.
Publicado: (2018)

In Silico Design for Adenosine Monophosphate-Activated Protein Kinase Agonist from Traditional Chinese Medicine for Treatment of Metabolic Syndromes
por: Tang, Hsin-Chieh, et al.
Publicado: (2014)

Adenosine monophosphate‐activated protein kinase is elevated in human cachectic muscle and prevents cancer‐induced metabolic dysfunction in mice
por: Raun, Steffen H., et al.
Publicado: (2023)

The potent, indirect adenosine monophosphate-activated protein kinase activator R419 attenuates mitogen-activated protein kinase signaling, inhibits nociceptor excitability, and reduces pain hypersensitivity in mice
por: Mejia, Galo L., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dunibv8ki3nfv3on11ao5fqna2