Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients

Mutations in superoxide dismutase-1 (SOD1) are a common known cause of amyotrophic lateral sclerosis (ALS). The neurotoxicity of mutant SOD1s is most likely caused by misfolded molecular species, but disease pathogenesis is still not understood. Proposed mechanisms include impaired mitochondrial fun...

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Detalles Bibliográficos
Autores principales: Keskin, Isil, Forsgren, Elin, Lange, Dale J., Weber, Markus, Birve, Anna, Synofzik, Matthis, Gilthorpe, Jonathan D., Andersen, Peter M., Marklund, Stefan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769150/
https://www.ncbi.nlm.nih.gov/pubmed/26919046
http://dx.doi.org/10.1371/journal.pone.0150133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769150/
https://www.ncbi.nlm.nih.gov/pubmed/26919046
http://dx.doi.org/10.1371/journal.pone.0150133

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