Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

The kinase Bub1 functions in the spindle assembly checkpoint (SAC) and in chromosome congression, but the role of its catalytic activity remains controversial. Here, we use two novel Bub1 inhibitors, BAY-320 and BAY-524, to demonstrate potent Bub1 kinase inhibition both in vitro and in intact cells....

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Detalles Bibliográficos
Autores principales: Baron, Anna P, von Schubert, Conrad, Cubizolles, Fabien, Siemeister, Gerhard, Hitchcock, Marion, Mengel, Anne, Schröder, Jens, Fernández-Montalván, Amaury, von Nussbaum, Franz, Mumberg, Dominik, Nigg, Erich A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769170/
https://www.ncbi.nlm.nih.gov/pubmed/26885717
http://dx.doi.org/10.7554/eLife.12187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769170/
https://www.ncbi.nlm.nih.gov/pubmed/26885717
http://dx.doi.org/10.7554/eLife.12187

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