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Binary architecture of the Na(v)1.2-β2 signaling complex
To investigate the mechanisms by which β-subunits influence Na(v) channel function, we solved the crystal structure of the β2 extracellular domain at 1.35Å. We combined these data with known bacterial Na(v) channel structural insights and novel functional studies to determine the interactions of spe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769172/ https://www.ncbi.nlm.nih.gov/pubmed/26894959 http://dx.doi.org/10.7554/eLife.10960 |