Cargando…

Lipoprotein X Causes Renal Disease in LCAT Deficiency

Human familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized by low HDL, accumulation of an abnormal cholesterol-rich multilamellar particle called lipoprotein-X (LpX) in plasma, and renal disease. The aim of our study was to determine if LpX is nephrotoxic and to gai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ossoli, Alice, Neufeld, Edward B., Thacker, Seth G., Vaisman, Boris, Pryor, Milton, Freeman, Lita A., Brantner, Christine A., Baranova, Irina, Francone, Nicolás O., Demosky, Stephen J., Vitali, Cecilia, Locatelli, Monica, Abbate, Mauro, Zoja, Carlamaria, Franceschini, Guido, Calabresi, Laura, Remaley, Alan T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769176/ https://www.ncbi.nlm.nih.gov/pubmed/26919698 http://dx.doi.org/10.1371/journal.pone.0150083

Ejemplares similares

LCAT protects against Lipoprotein‐X formation in a murine model of drug‐induced intrahepatic cholestasis
por: Amar, Marcelo J. A., et al.
Publicado: (2019)

Abnormal Lipoproteins Trigger Oxidative Stress-Mediated Apoptosis of Renal Cells in LCAT Deficiency
por: Gomaraschi, Monica, et al.
Publicado: (2023)

Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans
por: Pavanello, Chiara, et al.
Publicado: (2022)

Low Plasma Lecithin: Cholesterol Acyltransferase (LCAT) Concentration Predicts Chronic Kidney Disease
por: Baragetti, Andrea, et al.
Publicado: (2020)

High-Density Lipoproteins and the Kidney
por: Strazzella, Arianna, et al.
Publicado: (2021)

Endothelial Expression of Scavenger Receptor Class B, Type I Protects against Development of Atherosclerosis in Mice
por: Vaisman, Boris L., et al.
Publicado: (2015)

ApoA-I-Mediated Lipoprotein Remodeling Monitored with a Fluorescent Phospholipid
por: Neufeld, Edward B., et al.
Publicado: (2019)

Distant Homology Modeling of LCAT and Its Validation through In Silico Targeting and In Vitro and In Vivo Assays
por: Sensi, Cristina, et al.
Publicado: (2014)

Apolipoprotein C-II Mimetic Peptide Promotes the Plasma Clearance of Triglyceride-Rich Lipid Emulsion and the Incorporation of Fatty Acids into Peripheral Tissues of Mice
por: Komatsu, Tomohiro, et al.
Publicado: (2019)

High-Density Lipoprotein, Lecithin: Cholesterol Acyltransferase, and Atherosclerosis
por: Ossoli, Alice, et al.
Publicado: (2016)

rHDL modeling and the anchoring mechanism of LCAT activation
por: Laurenzi, Tommaso, et al.
Publicado: (2020)

Novel missense variants in LCAT and APOB genes in an Italian kindred with familial lecithin:cholesterol acyltransferase deficiency and hypobetalipoproteinemia
por: Conca, Paola, et al.
Publicado: (2012)

A Simple Fluorescent Cholesterol Labeling Method to Cryoprotect and Detect Plasma Lipoprotein-X
por: Neufeld, Edward B., et al.
Publicado: (2022)

Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins
por: Zannis, Vassilis I., et al.
Publicado: (2017)

DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass
por: Gordon, Scott M., et al.
Publicado: (2019)

Lipid Profile Rather Than the LCAT Mutation Explains Renal Disease in Familial LCAT Deficiency
por: Lamiquiz-Moneo, Itziar, et al.
Publicado: (2019)

First-in-human autologous implantation of genetically modified adipocytes expressing LCAT for the treatment of familial LCAT deficiency
por: Aso, Masayuki, et al.
Publicado: (2022)

Two novel variants in the lecithin:cholesterol acyltransferase gene resulted in classic LCAT deficiency
por: Fistrek Prlic, Margareta, et al.
Publicado: (2022)

Association Between Lipids, Lipoproteins Composition of HDL Particles and Triglyceride-Rich Lipoproteins, and LCAT and CETP Activity in Post-renal Transplant Patients
por: Kimak, Elżbieta, et al.
Publicado: (2013)

Current Status of Familial LCAT Deficiency in Japan
por: Kuroda, Masayuki, et al.
Publicado: (2021)

Add-On Cyclic Angiotensin-(1-7) with Cyclophosphamide Arrests Progressive Kidney Disease in Rats with ANCA Associated Glomerulonephritis
por: Cerullo, Domenico, et al.
Publicado: (2022)

Endothelial Glycocalyx of Peritubular Capillaries in Experimental Diabetic Nephropathy: A Target of ACE Inhibitor-Induced Kidney Microvascular Protection
por: Locatelli, Monica, et al.
Publicado: (2023)

Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets
por: Zoja, Carlamaria, et al.
Publicado: (2020)

Toxoplasma gondii LCAT Primarily Contributes to Tachyzoite Egress
por: Schultz, Aric J., et al.
Publicado: (2018)

Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat Diet through Lipotoxicity-Induced Mitochondrial Damage
por: Locatelli, Monica, et al.
Publicado: (2022)

A previously unrecognized role of C3a in proteinuric progressive nephropathy
por: Morigi, Marina, et al.
Publicado: (2016)

Short hydrocarbon stapled ApoC2-mimetic peptides activate lipoprotein lipase and lower plasma triglycerides in mice
por: Sviridov, Denis, et al.
Publicado: (2023)

Complement Activation Contributes to the Pathophysiology of Shiga Toxin-Associated Hemolytic Uremic Syndrome
por: Buelli, Simona, et al.
Publicado: (2019)

Shiga Toxin 2 Triggers C3a-Dependent Glomerular and Tubular Injury through Mitochondrial Dysfunction in Hemolytic Uremic Syndrome
por: Buelli, Simona, et al.
Publicado: (2022)

Familial lecithin-cholesterol acyltransferase (LCAT) deficiency; a differential of proteinuria
por: Althaf, Mohammed Mahdi, et al.
Publicado: (2015)

LCAT: an isoform-sensitive error correction for transcriptome sequencing long reads
por: Zhu, Wufei, et al.
Publicado: (2023)

Renal Expression of FGF23 in Progressive Renal Disease of Diabetes and the Effect of Ace Inhibitor
por: Zanchi, Cristina, et al.
Publicado: (2013)

Low Nephron Number Induced by Maternal Protein Restriction Is Prevented by Nicotinamide Riboside Supplementation Depending on Sirtuin 3 Activation
por: Pezzotta, Anna, et al.
Publicado: (2022)

Diet-Induced Weight Loss in Overweight or Obese Women and Changes in High-Density Lipoprotein Levels and Function
por: Aicher, Brittany O., et al.
Publicado: (2012)

LCAT deficiency: a systematic review with the clinical and genetic description of Mexican kindred
por: Mehta, Roopa, et al.
Publicado: (2021)

Cellular Localization and Trafficking of the Human ABCG1 Transporter
por: Neufeld, Edward B., et al.
Publicado: (2014)

An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level
por: Balwani, Manish R, et al.
Publicado: (2016)

LCAT, ApoD, and ApoA1 Expression and Review of Cholesterol Deposition in the Cornea
por: Flores, Rhonda, et al.
Publicado: (2019)

Metabolism of PLTP, CETP, and LCAT on multiple HDL sizes using the Orbitrap Fusion Lumos
por: Singh, Sasha A., et al.
Publicado: (2021)

Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes
por: Locatelli, Monica, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ur3coppgbgc6o25etdvhcpllqc