An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells

DNA methylation is extensively remodeled during mammalian gametogenesis and embryogenesis. Most transposons become hypomethylated, raising the question of their regulation in the absence of DNA methylation. To reproduce a rapid and extensive demethylation, we subjected mouse ES cells to chemically d...

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Detalles Bibliográficos
Autores principales: Walter, Marius, Teissandier, Aurélie, Pérez-Palacios, Raquel, Bourc'his, Déborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Developmental Biology and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769179/
https://www.ncbi.nlm.nih.gov/pubmed/26814573
http://dx.doi.org/10.7554/eLife.11418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769179/
https://www.ncbi.nlm.nih.gov/pubmed/26814573
http://dx.doi.org/10.7554/eLife.11418

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