Down-Regulation of Surface CD28 under Belatacept Treatment: An Escape Mechanism for Antigen-Reactive T-Cells

BACKGROUND: The co-stimulatory inhibitor of the CD28-CD80/86-pathway, belatacept, allows calcineurin-inhibitor-free immunosuppression in kidney transplantation. However, aggressive T-cell mediated allogeneic responses have been observed in belatacept-treated patients, which could be explained by eff...

Descripción completa

Detalles Bibliográficos
Autores principales: de Graav, Gretchen N., Hesselink, Dennis A., Dieterich, Marjolein, Kraaijeveld, Rens, Weimar, Willem, Baan, Carla C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769294/
https://www.ncbi.nlm.nih.gov/pubmed/26919152
http://dx.doi.org/10.1371/journal.pone.0148604

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769294/
https://www.ncbi.nlm.nih.gov/pubmed/26919152
http://dx.doi.org/10.1371/journal.pone.0148604

Ejemplares similares