Affinity Enhancement by Ligand Clustering Effect Inspired by Peptide Dendrimers−Shank PDZ Proteins Interactions

High-affinity binders are desirable tools to probe the function that specific protein−protein interactions play in cell. In the process of seeking a general strategy to design high-affinity binders, we found a clue from the βPIX (p21-activated kinase interacting exchange factor)−Shank PDZ interactio...

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Detalles Bibliográficos
Autores principales: Liu, Jiahui, Liu, Miao, Zheng, Bo, Yao, Zhongping, Xia, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769301/
https://www.ncbi.nlm.nih.gov/pubmed/26918521
http://dx.doi.org/10.1371/journal.pone.0149580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769301/
https://www.ncbi.nlm.nih.gov/pubmed/26918521
http://dx.doi.org/10.1371/journal.pone.0149580

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