Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

BACKGROUND: Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we inv...

Descripción completa

Detalles Bibliográficos
Autores principales: Bashari, Muhammad Hasan, Fan, Fengjuan, Vallet, Sonia, Sattler, Martin, Arn, Melissa, Luckner-Minden, Claudia, Schulze-Bergkamen, Henning, Zörnig, Inka, Marme, Frederik, Schneeweiss, Andreas, Cardone, Michael H., Opferman, Joseph T., Jäger, Dirk, Podar, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769490/
https://www.ncbi.nlm.nih.gov/pubmed/26921175
http://dx.doi.org/10.1186/s13058-016-0686-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769490/
https://www.ncbi.nlm.nih.gov/pubmed/26921175
http://dx.doi.org/10.1186/s13058-016-0686-4

Ejemplares similares