Cargando…

Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

BACKGROUND: Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we inv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bashari, Muhammad Hasan, Fan, Fengjuan, Vallet, Sonia, Sattler, Martin, Arn, Melissa, Luckner-Minden, Claudia, Schulze-Bergkamen, Henning, Zörnig, Inka, Marme, Frederik, Schneeweiss, Andreas, Cardone, Michael H., Opferman, Joseph T., Jäger, Dirk, Podar, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769490/ https://www.ncbi.nlm.nih.gov/pubmed/26921175 http://dx.doi.org/10.1186/s13058-016-0686-4

Ejemplares similares

Pre-Osteoblasts Stimulate Migration of Breast Cancer Cells via the HGF/MET Pathway
por: Vallet, Sonia, et al.
Publicado: (2016)

Co-Stimulatory Bispecific Antibodies Induce Enhanced T Cell Activation and Tumor Cell Killing in Breast Cancer Models
por: Warwas, Karsten M., et al.
Publicado: (2021)

Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction
por: Schulze-Bergkamen, Henning, et al.
Publicado: (2006)

Male sterility in Mcl-1-flox mice is not due to enhanced Mcl1 protein stability
por: Ah-Cann, Casey, et al.
Publicado: (2016)

In silico SNP analysis of the breast cancer antigen NY-BR-1
por: Kosaloglu, Zeynep, et al.
Publicado: (2016)

The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis
por: Flemmer, Robert T., et al.
Publicado: (2021)

Mcl-1 is a key regulator of the ovarian reserve
por: Omari, S, et al.
Publicado: (2015)

MCL-1–dependent leukemia cells are more sensitive to chemotherapy than BCL-2–dependent counterparts
por: Brunelle, Joslyn K., et al.
Publicado: (2009)

Use of Taxanes in Metastatic HER2-negative Breast Cancer – a Status Report
por: Gluz, Oleg, et al.
Publicado: (2020)

Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors
por: Floros, Konstantinos V., et al.
Publicado: (2021)

Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy
por: Rahbari, Nuh N, et al.
Publicado: (2014)

MCL-1 is a master regulator of cancer dependency on fatty acid oxidation
por: Prew, Michelle S., et al.
Publicado: (2022)

Liver cancers with stem/progenitor-cell features – a rare chemotherapy-sensitive malignancy
por: Köhler, Bruno Christian, et al.
Publicado: (2017)

MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice
por: Healy, Marc E., et al.
Publicado: (2020)

The Role of AP-1 Transcription Factors in Plasma Cell Biology and Multiple Myeloma Pathophysiology
por: Fan, Fengjuan, et al.
Publicado: (2021)

Dysregulated Host Response in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Critical Illness
por: Tiwari-Heckler, Shilpa, et al.
Publicado: (2021)

Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma
por: Ahmed, Azaz, et al.
Publicado: (2022)

Subgroup analysis of patients with HER2-negative metastatic breast cancer in the second-line setting from a phase 3, open-label, randomized study of eribulin mesilate versus capecitabine
por: Pivot, Xavier, et al.
Publicado: (2018)

Phase Ib study evaluating safety and clinical activity of the anti-HER3 antibody lumretuzumab combined with the anti-HER2 antibody pertuzumab and paclitaxel in HER3-positive, HER2-low metastatic breast cancer
por: Schneeweiss, Andreas, et al.
Publicado: (2018)

Peripheral blood and tissue assessment highlights differential tumor-circulatory gradients of IL2 and MIF with prognostic significance in resectable pancreatic ductal adenocarcinoma
por: Ahmed, Azaz, et al.
Publicado: (2021)

Beyond Cell Death – Antiapoptotic Bcl-2 Proteins Regulate Migration and Invasion of Colorectal Cancer Cells In Vitro
por: Koehler, Bruno Christian, et al.
Publicado: (2013)

The impact of human adipose tissue-derived stem cells on breast cancer cells: implications for cell-assisted lipotransfers in breast reconstruction
por: Koellensperger, Eva, et al.
Publicado: (2017)

Preclinical efficacy of sepantronium bromide (YM155) in multiple myeloma is conferred by down regulation of Mcl-1
por: Wagner, Verena, et al.
Publicado: (2014)

An undifferentiated carcinoma at Klatskin-position with long-term complete remission after chemotherapy
por: Köhler, Bruno Christian, et al.
Publicado: (2018)

Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting
por: Chen, Hongda, et al.
Publicado: (2016)

A nonviral, nonintegrating DNA nanovector platform for the safe, rapid, and persistent manufacture of recombinant T cells
por: Bozza, Matthias, et al.
Publicado: (2021)

Targeting the Tumor Microenvironment: Focus on Angiogenesis
por: Fan, Fengjuan, et al.
Publicado: (2012)

The Ethyl Acetate Fraction of Marine Sponge Stylissa carteri Induces Breast Cancer Cell Death via Upregulation of Mcl-1S: an In vitro Study
por: Bashari, Muhammad Hasan, et al.
Publicado: (2022)

The MCL-1 BH3 Helix is an Exclusive MCL-1 inhibitor and Apoptosis Sensitizer
por: Stewart, Michelle L., et al.
Publicado: (2010)

Outcomes Following ACL and Grade III MCL Injuries: Is there a Role for MCL Repair?
por: Westermann, Robert W., et al.
Publicado: (2017)

PorthoMCL: Parallel orthology prediction using MCL for the realm of massive genome availability
por: Tabari, Ehsan, et al.
Publicado: (2017)

Dual-Targeted Therapy in HER2-Overexpressing Breast Cancer with Trastuzumab and Novel Cholesterol-Based Nioplexes Silencing Mcl-1
por: Pengnam, Supusson, et al.
Publicado: (2023)

Which Fibers of the Medial Collateral Ligament (MCL) Should Be Released in the Pie Crust Technique Applied During Knee Arthroscopy: Superficial MCL or Deep MCL?
por: Arıcan, Gökhun, et al.
Publicado: (2021)

Mcl-1 Ubiquitination and Destruction
por: Inuzuka, Hiroyuki, et al.
Publicado: (2011)

Evaluation of the diagnostic value of 64 simultaneously measured autoantibodies for early detection of gastric cancer
por: Werner, Simone, et al.
Publicado: (2016)

A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB1*0401 transgenic mice
por: Das, Krishna, et al.
Publicado: (2019)

Rapid MALDI-MS Assays for Drug Quantification in Biological Matrices: Lessons Learned, New Developments, and Future Perspectives
por: Fresnais, Margaux, et al.
Publicado: (2021)

Knockdown of Atg7 Induces Nuclear-LC3 Dependent Apoptosis and Augments Chemotherapy in Colorectal Cancer Cells
por: Scherr, Anna-Lena, et al.
Publicado: (2020)

Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies
por: Vallet, Sonia, et al.
Publicado: (2018)

Combined Mcl-1 and YAP1/TAZ inhibition for treatment of metastatic uveal melanoma
por: Glinkina, Kseniya A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_m2ubi9geac30btvt5oj89rh7f9