Improvement in detection of minor alleles in next generation sequencing by base quality recalibration

BACKGROUND: Minor allele detection in very high coverage sequence data (>1000X) has many applications such as detecting mtDNA heteroplasmy, somatic mutations in cancer or tumors, SNP calling in pool sequencing, etc., where reads with low frequency are not necessarily sequence error but may instea...

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Detalles Bibliográficos
Autores principales: Ni, Shengyu, Stoneking, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769523/
https://www.ncbi.nlm.nih.gov/pubmed/26920804
http://dx.doi.org/10.1186/s12864-016-2463-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769523/
https://www.ncbi.nlm.nih.gov/pubmed/26920804
http://dx.doi.org/10.1186/s12864-016-2463-2

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