Cargando…

Synthesis, In Vivo Anti-Inflammatory Activity, and Molecular Docking Studies of New Isatin Derivatives

A novel synthesis of 2-hydroxy-N′-(2-oxoindolin-3-ylidene) benzohydrazide derivatives was synthesized by the condensation of 2-hydroxybenzohydrazide with substituted isatins. The synthesized compounds were characterized by FT-IR, (1)H-NMR, and mass spectral data. Further, the compounds were screened...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jarapula, Ravi, Gangarapu, Kiran, Manda, Sarangapani, Rekulapally, Sriram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769772/ https://www.ncbi.nlm.nih.gov/pubmed/27022484 http://dx.doi.org/10.1155/2016/2181027

Ejemplares similares

Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
por: Gangarapu, Kiran, et al.
Publicado: (2013)

Design, synthesis, molecular docking and DFT studies on novel melatonin and isatin based azole derivatives
por: Saini, Keshav Kumar, et al.
Publicado: (2023)

Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Isatin-Thiazole Derivatives as α-Glucosidase Inhibitors
por: Xie, Zhenzhen, et al.
Publicado: (2017)

Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors
por: Firoozpour, Loghman, et al.
Publicado: (2020)

Design, synthesis, docking, and antidepressant activity evaluation of isatin derivatives bearing Schiff bases
por: Mesripour, Azadeh, et al.
Publicado: (2023)

QSAR and molecular docking studies of isatin and indole derivatives as SARS 3CL(pro) inhibitors
por: Soleymani, Niousha, et al.
Publicado: (2023)

Synthesis, Characterization, and Antibacterial Activity of New Isatin Derivatives
por: Nain, Sumitra, et al.
Publicado: (2023)

Design, One Pot Synthesis and Molecular Docking Studies of Substituted-1H-Pyrido[2,1-b] Quinazolines as Apoptosis-Inducing Anticancer Agents
por: Bathula, Raju, et al.
Publicado: (2020)

Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates
por: Ibrahim, Musab Mohamed, et al.
Publicado: (2018)

Synthesis, antitubercular and anticancer activity of new Baylis–Hillman adduct-derived N-cinnamyl-substituted isatin derivatives
por: Kumar, Sriramoju Bharath, et al.
Publicado: (2013)

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
por: Elkaeed, Eslam B., et al.
Publicado: (2022)

Novel anti-inflammatory and analgesic agents: synthesis, molecular docking and in vivo studies
por: Ugwu, David Izuchukwu, et al.
Publicado: (2018)

Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors
por: Czeleń, Przemysław, et al.
Publicado: (2022)

Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides
por: Selvam, P., et al.
Publicado: (2008)

Synthesis and Preliminary Antimicrobial Analysis of Isatin–Ferrocene and Isatin–Ferrocenyl Chalcone Conjugates
por: Singh, Amandeep, et al.
Publicado: (2018)

Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
por: Abbas, Samir Y., et al.
Publicado: (2013)

Synthesis and Antiproliferatory Activities Evaluation of Multi-Substituted Isatin Derivatives
por: Ding, Ying, et al.
Publicado: (2020)

Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors
por: Liu, Wei, et al.
Publicado: (2014)

Anticancer Effects with Molecular Docking Confirmation of Newly Synthesized Isatin Sulfonamide Molecular Hybrid Derivatives against Hepatic Cancer Cell Lines
por: Eldeeb, Mahmoud, et al.
Publicado: (2022)

Evaluation of Anti-Neuroinflammatory Activity of Isatin Derivatives in Activated Microglia
por: Cenalmor, Alejandro, et al.
Publicado: (2023)

PA-Int5: An isatin-thiosemicarbazone derivative that exhibits anti-nociceptive and anti-inflammatory effects in Swiss mice
por: Da Fonseca, Aldilane Gonçalves, et al.
Publicado: (2021)

Synthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives
por: Chinnasamy, Rajaram Prakash, et al.
Publicado: (2010)

Antiproliferative Activity, Multikinase Inhibition, Apoptosis- Inducing Effects and Molecular Docking of Novel Isatin–Purine Hybrids
por: Alanazi, Ashwag S., et al.
Publicado: (2023)

1H-1,2,3-Triazole Tethered Nitroimidazole–Isatin Conjugates: Synthesis, Docking, and Anti-Proliferative Evaluation against Breast Cancer
por: Kumar, Sumit, et al.
Publicado: (2018)

Synthesis, Spectroscopic Characterization and Antimicrobial Potential of Certain New Isatin-Indole Molecular Hybrids
por: Al-Wabli, Reem I., et al.
Publicado: (2017)

Tryptanthrin from microwave-assisted reduction of isatin using solid-state-supported sodium borohydride: DFT calculations, molecular docking and evaluation of its analgesic and anti-inflammatory activity
por: Obafemi, Craig A., et al.
Publicado: (2020)

Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies
por: El-Azab, Adel S., et al.
Publicado: (2017)

Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds
por: Abdelgawad, Mohamed A, et al.
Publicado: (2022)

Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone
por: Ke, Shaoyong, et al.
Publicado: (2019)

Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells
por: El-Saied, Fathy, et al.
Publicado: (2019)

Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents
por: Sayed, Amira I., et al.
Publicado: (2022)

Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives
por: Taha, Muhammad, et al.
Publicado: (2019)

Azide–Alkyne Cycloaddition En Route to 1H-1,2,3-Triazole-Tethered Isatin–Ferrocene, Ferrocenylmethoxy–Isatin, and Isatin–Ferrocenylchalcone Conjugates: Synthesis and Antiproliferative Evaluation
por: Singh, Amandeep, et al.
Publicado: (2018)

Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors
por: Chen, Li-Rung, et al.
Publicado: (2005)

Isatin-benzoazine molecular hybrids as potential antiproliferative agents: synthesis and in vitro pharmacological profiling
por: Abdel-Aziz, Hatem A, et al.
Publicado: (2017)

Design, synthesis and molecular modeling of isatin-aminobenzoic acid hybrids as antibacterial and antibiofilm agents
por: Radwan, Awwad A., et al.
Publicado: (2023)

Anti-Toxoplasma gondii activity of 5-oxo-hexahydroquinoline derivatives: synthesis, in vitro and in vivo evaluations, and molecular docking analysis
por: Zahedi, Mohammadsaeid, et al.
Publicado: (2020)

Synthesis, Anticancer, Antioxidant, Anti-Inflammatory, Antimicrobial Activities, Molecular Docking, and DFT Studies of Sultams Derived from Saccharin
por: Al-Fayez, Nourah, et al.
Publicado: (2022)

Design, synthesis and anti-breast cancer properties of butyric ester tethered dihydroartemisinin-isatin hybrids
por: Zhao, Shijia, et al.
Publicado: (2023)

Morita–Baylis–Hillman reaction of acrylamide with isatin derivatives
por: Singh, Radhey Mohan, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_2mvdf3doeuet8vsob5vlsgrhdl