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Neurons in Vulnerable Regions of the Alzheimer’s Disease Brain Display Reduced ATM Signaling123

Ataxia telangiectasia (A-T) is a multisystemic disease caused by mutations in the ATM (A-T mutated) gene. It strikes before 5 years of age and leads to dysfunctions in many tissues, including the CNS, where it leads to neurodegeneration, primarily in cerebellum. Alzheimer’s disease (AD), by contrast...

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Detalles Bibliográficos
Autores principales: Shen, Xuting, Chen, Jianmin, Li, Jiali, Kofler, Julia, Herrup, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770009/
https://www.ncbi.nlm.nih.gov/pubmed/27022623
http://dx.doi.org/10.1523/ENEURO.0124-15.2016