ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice

Collagen IV is a major component of basement membranes, and mutations in COL4A1, which encodes collagen IV alpha chain 1, cause a multisystemic disease encompassing cerebrovascular, eye and kidney defects. However, COL4A1 renal disease remains poorly characterized and its pathomolecular mechanisms a...

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Detalles Bibliográficos
Autores principales: Jones, Frances E., Bailey, Matthew A., Murray, Lydia S., Lu, Yinhui, McNeilly, Sarah, Schlötzer-Schrehardt, Ursula, Lennon, Rachel, Sado, Yoshikazu, Brownstein, David G., Mullins, John J., Kadler, Karl E., Van Agtmael, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770143/
https://www.ncbi.nlm.nih.gov/pubmed/26839400
http://dx.doi.org/10.1242/dmm.021741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770143/
https://www.ncbi.nlm.nih.gov/pubmed/26839400
http://dx.doi.org/10.1242/dmm.021741

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