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Using the mouse to model human disease: increasing validity and reproducibility

Experiments that use the mouse as a model for disease have recently come under scrutiny because of the repeated failure of data, particularly derived from preclinical studies, to be replicated or translated to humans. The usefulness of mouse models has been questioned because of irreproducibility an...

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Detalles Bibliográficos
Autores principales: Justice, Monica J., Dhillon, Paraminder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770152/
https://www.ncbi.nlm.nih.gov/pubmed/26839397
http://dx.doi.org/10.1242/dmm.024547