The first crystal structures of RNA–PNA duplexes and a PNA-PNA duplex containing mismatches—toward anti-sense therapy against TREDs

PNA is a promising molecule for antisense therapy of trinucleotide repeat disorders. We present the first crystal structures of RNA–PNA duplexes. They contain CUG repeats, relevant to myotonic dystrophy type I, and CAG repeats associated with poly-glutamine diseases. We also report the first PNA–PNA...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiliszek, Agnieszka, Banaszak, Katarzyna, Dauter, Zbigniew, Rypniewski, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770230/
https://www.ncbi.nlm.nih.gov/pubmed/26717983
http://dx.doi.org/10.1093/nar/gkv1513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770230/
https://www.ncbi.nlm.nih.gov/pubmed/26717983
http://dx.doi.org/10.1093/nar/gkv1513

Ejemplares similares