Unfolding the HIV-1 reverse transcriptase RNase H domain – how to lose a molecular tug-of-war

Formation of the mature HIV-1 reverse transcriptase (RT) p66/p51 heterodimer requires subunit-specific processing of the p66/p66′ homodimer precursor. Since the ribonuclease H (RH) domain contains an occult cleavage site located near its center, cleavage must occur either prior to folding or subsequ...

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Detalles Bibliográficos
Autores principales: Zheng, Xunhai, Pedersen, Lars C., Gabel, Scott A., Mueller, Geoffrey A., DeRose, Eugene F., London, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770237/
https://www.ncbi.nlm.nih.gov/pubmed/26773054
http://dx.doi.org/10.1093/nar/gkv1538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770237/
https://www.ncbi.nlm.nih.gov/pubmed/26773054
http://dx.doi.org/10.1093/nar/gkv1538

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